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Crizotinib

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• Place of Origin:china

Quality Guarentee Small Molecular API Crizotinib

(CAS# 877399-52-5)



Chemical Information

Product Name	Crizotinib
Molecular Formula	C21H22Cl2FN5O
Molecular Weight	450.34
Storage	Store at -20°C
Targets	c-Met ALK
IC50	11 nM 24 nM

Description

Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.

Application

The inhibitory effects of crizotinib on MP cells and SP cells were determined by colony formation assay. The IC50 value of crizotinib for MP cells was 21.3 nM. Of note, the SP cells showed no significant changes after crizotinib treatment. However, the SP cells showed a cell survival rate of 50.0±0.6% following a combined treatment of crizotinib (22.4 nM) and verapamil (500 µM), compared with 105.3±0.4% survival of SP cells treated with crizotinib (22.4 nM) alone. The growth curves obtained demonstrate that crizotinib inhibited the growth of SP and MP cells, and this inhibition was dependent on both concentration and time.

Tumorigenicity was examined using immune-deficient mice, into which SP or MP cells of LLC were subcutaneously transplanted. Nonsorted LLC cells formed xenografts in mice at 1x105 cells. Tumor size was significantly decreased in the crizotinib-treated LLC groups (225±29 mm3) compared to the untreated group (PBS: 834±41 mm3) by 40 days after treatment.

COA:

Test Items	Specification	Results
Description	White to off white crystalline powder	Comply
Melting point	166-170°C	167.3-168.1°C
Identification	Positive reaction	Positive reaction
Related substances	≤1.0%	0.16%
Loss on drying	≤0.5%	0.06%
Residue on ignition	≤0.1%	0.02%
Chloride	≤0.014%	<0.014
Heavy Metals	≤20ppm	<20ppm
Clarity of solution	Conform to standard	Complies
Microbial Limit	≤20ppm	<20ppm
Assay	≥99.0%	99.12%

FEATURED PRODUCT:

Wuhan Newbio Pharm-tech Co., Ltd.
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18	15663-27-1	Cisplatin	40	709031-78-7	Saxagliptin Hydrochloride
19	877399-52-5	Crizotinib	41	486460-32-6	Sitagliptin
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23	25316-40-9	Doxorubicin hydrochloride	46	540737-29-9	Tofacitinib Citrate
24	133040-01-4	Eprosartan	47	170791-09-0	Trityl Candesartan Cilexetil

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