Secretin Acetate

Product Name Secretin Acetate

Sequence H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-

Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-

Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

Cas No. 17034-35-4

Molecular Formula C130H220N44O41

Molecular Weight 3055.47

Purity (HPLC) 98.0%min.

Appearance? White powder

Single Impurity (HPLC)? 1.0%max

Amino Acid Composition? ±10% of theoretical

Peptide Content (N%) ?≥80.0%

Water Content(Karl Fischer)? ≤6.0%

Applications:

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine