98% Adipotide 2mg/vial jeana@yccreate.com

98% Adipotide 2mg/vial jeana@yccreate.com

Basic Info

Model NO.: API

Customized: Customized

Suitable for: Adult

Purity: >98%

Appearance: Powder

Storage: 2-8

Name: Glucagon-Like Peptide 1 (7-36) Amide

Transport Package: Bottled

Powder: Yes

Certification: GMP

State: Powder/Finished

Colour: White

Brand: Filter

CAS: 107444-51-9

Specification: iu, mg, g, bottled, box

HS Code: 3002200000

Product Description

Peptides GLP(7-36)

GLP-1 (7-36) amide is an incretin hormone that causes glucose dependent release of by pancreatic beta cells. It is the cleavage product of GLP-1 (1-36) amide peptide (Cat# AS-22460). Both GLP-1 (7-36) and GLP-1 (7-37)-Cat# AS-20761, also play roles in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of . GLP-1 (7-36) has a short half life of less than 2 minutes, and like GIP, is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4), which is widely expressed in a number of sites, including the endothelial cells of small gut arterioles. DPP-4 degrades GLP-1 (7-36) into the non insulinotropic GLP-1 (9-36)-Cat# AS-65070 (some studies suggest it may have weak insulinotropic activity). As a result, the majority of GLP-1 (and GIP) is inactivated as an insulinotrope before reaching the systemic circulation.

Glucagon-like peptide 1 (GLP-1) (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor (pIC50 = 8.5) in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression, inhibiting β-cell apoptosis, promoting β-cell neogenesis, reducing glucagon secretion, delaying gastric emptying, promoting satiety, and increasing peripheral glucose disposal.