Larocaine Anesthesia Injection CAS 94-15-5 safe delivery free sample
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(DMC, larocaine), a synthetic derivative of co-caine, is a widely distributed \"legal high\" consumed as a \"new psychoactive substance\" (NPS), originally was used in the 1930s as an anesthetic, primarily in dentistry, ophthalmology, and otolaryngology. This drug completely inhibits dopamine transporter and has had the potential for abuse. Dimetho-caine is intended for forensic and research purposes.
Sample USE GUIDE
In Vivo Use Guide
in rhesus monkeys: When responding was stable, dimetho-caine (0.030-1.7 mg/kg/ infusion) was substituted for the cocaine training dose. Dimetho-caine administration produced higher response rates compared with that of procaine, and was a more potent reinforcer. Drug effects on behavior were related to DAT occupancy in monkey striatum during neuroimaging with positron emission tomography (PET). DAT occupancy was determined by displacement of 8-(2-[(18)F]fluroethyl)2beta-carbomethoxy-3beta-(4-chlorophenyl)nortropane (FECNT). DAT occupancy was between 66 and 82% and <10-41% for doses of dimetho-caine and procaine that maintained maximum response rates, respectively. Acute administration of dimetho-caine (10-40 mg/kg, IP) significantly increased locomotor activity and time spent on the drug-paired side and reduced the relative number of entries and time spent on the open arms of the plus-maze in mice.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Dimetho-caine showed full displacement of [3H]2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane 1.5-naphthalenedisulfonate (CFT) binding (0-30 microM tested) and full inhibition of dopamine uptake (0-100 microM tested). Dimetho-caine was only slightly less potent than cocaine with an estimated Ki of 1.4 micorM and an IC50 value of 1.2 microM for [3H]CFT binding and dopamine uptake.
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Items | Standard | Results of analysis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Appearance | White to class white powder | Class white powder | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solubility | Almost insoluble in water, soluble in dimethyl sulfoxide, slightly soluble in dichloromethane | Conforms | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Speicific rotation | +78.0°~+84.0° | +82.3° | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ordinary impurities (Do not calculate isomer A+C) | Single impurity≤0.15% | 0.03% | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total impurities≤1.0% | 0.09% | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Calculate isomer | A≤0.15% | 0.02% | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
B≤0.1% | Not detected | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
C≤0.1% | Not detected | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Loss on drying | ≤0.5% | 0.31% | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Residue on ignition | ≤0.1% | Conforms | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Heavy metal | 20ppm | Conforms | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Assay | 97.5%-102.0% | 99.8% | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Conclusion :The test results conform with USP36.
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